Trikafta rescues CFTR and lowers monocyte P2X7R-induced inflammasome activation in cystic fibrosis

C Gabillard-Lefort, M Casey, AMA Glasgow… - American journal of …, 2022 - atsjournals.org
Rationale: Cystic fibrosis (CF) is caused by mutations in the CFTR (CF transmembrane
conductance regulator) gene and is characterized by sustained inflammation. ATP triggers IL-1β …

[HTML][HTML] Precise targeting of miRNA sites restores CFTR activity in CF bronchial epithelial cells

…, EF Fernández, R Gaul, S Vencken, A Glasgow… - Molecular Therapy, 2020 - cell.com
MicroRNAs that are overexpressed in cystic fibrosis (CF) bronchial epithelial cells (BEC)
negatively regulate CFTR and nullify the beneficial effects of CFTR modulators. We …

Non-coding RNA in cystic fibrosis

AMA Glasgow, C De Santi… - Biochemical Society …, 2018 - portlandpress.com
Non-coding RNAs (ncRNAs) are an abundant class of RNAs that include small ncRNAs,
long non-coding RNAs (lncRNA) and pseudogenes. The human ncRNA atlas includes …

[HTML][HTML] A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation

…, ML Zani, DJ Quinn, S Dallet-Choisy, AMA Glasgow… - Molecular Therapy, 2015 - cell.com
Elafin is a serine protease inhibitor produced by epithelial and immune cells with anti-inflammatory
properties. Research has shown that dysregulated protease activity may elicit …

[HTML][HTML] Sexual dimorphism in interstitial lung disease

M Ozaki, A Glasgow, IK Oglesby, WL Ng, S Kelly… - Biomedicines, 2022 - mdpi.com
Interstitial lung diseases (ILD) are a group of heterogeneous progressive pulmonary disorders,
characterised by tissue remodelling and/or fibrotic scarring of the lung parenchyma. ILD …

[HTML][HTML] Alpha-1 antitrypsin—a target for microRNA-based therapeutic development for cystic fibrosis

AMD Hunt, AMA Glasgow, H Humphreys… - International journal of …, 2020 - mdpi.com
Cystic fibrosis (CF) is an autosomal recessive genetic disorder arising from mutations to the
cystic fibrosis transmembrane conductance regulator (CFTR) gene. Disruption to normal ion …

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung

AMA Glasgow, DM Small, A Scott, DT McLean… - Thorax, 2015 - thorax.bmj.com
Introduction Secretory leucocyte protease inhibitor and elafin are members of the whey acidic
protein (WAP), or WAP four disulfide-core (WFDC), family of proteins and have multiple …

[HTML][HTML] An evaluation of an open access iPSC training course:“How to model interstitial lung disease using patient-derived iPSCs”

A Schweikert, S Kenny, I Oglesby, A Glasgow… - Stem Cell Research & …, 2023 - Springer
Background Interstitial lung diseases (ILD) are a group of rare lung diseases with severe
outcomes. The COST Innovator Grant aims to establish a first-of-a-kind open-access …

Epigenetic mechanisms underpinning sexual dimorphism in lung disease

AMA Glasgow, CM Greene - Epigenomics, 2022 - Future Medicine
Arlene MA GlasgowArlene MA Glasgow … Correlations between miR-224-5p levels and
lung function and exacerbation rates were also noted (Glasgow & Greene, unpublished Data) …

Epithelial damage in the cystic fibrosis lung: the role of host and microbial factors

AMA Glasgow, CM Greene - Expert Review of Respiratory …, 2022 - Taylor & Francis
Introduction The airway epithelium is a key system within the lung. It acts as a physical barrier
to inhaled factors, and can actively remove unwanted microbes and particles from the lung …