User profiles for Anthony J. Garcia-Prats
 | Anthony Garcia-PratsDepartment of Paediatrics and Child Health, Stellenbosch University Verified email at sun.ac.za Cited by 2477 |
[HTML][HTML] Treatment and outcomes in children with multidrug-resistant tuberculosis: a systematic review and individual patient data meta-analysis
EP Harausz, AJ Garcia-Prats, S Law, HS Schaaf… - PLoS …, 2018 - journals.plos.org
Background An estimated 32,000 children develop multidrug-resistant tuberculosis (MDR-TB;
Mycobacterium tuberculosis resistant to isoniazid and rifampin) each year. Little is known …
Mycobacterium tuberculosis resistant to isoniazid and rifampin) each year. Little is known …
Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis
…, P Escalante, D Falzon, AJ Garcia-Prats… - The lancet respiratory …, 2018 - thelancet.com
Background Isoniazid-resistant, rifampicin-susceptible (INH-R) tuberculosis is the most common
form of drug resistance, and is associated with failure, relapse, and acquired rifampicin …
form of drug resistance, and is associated with failure, relapse, and acquired rifampicin …
Compassionate use of new drugs in children and adolescents with multidrug-resistant and extensively drug-resistant tuberculosis: early experiences and challenges
M Tadolini, AJ Garcia-Prats… - European …, 2016 - Eur Respiratory Soc
The World Health Organization (WHO) estimated that 480 000 new multidrug-resistant (MDR)
tuberculosis (TB) cases occurred globally in 2014, with 190 000 deaths. Limited data are …
tuberculosis (TB) cases occurred globally in 2014, with 190 000 deaths. Limited data are …
New and repurposed drugs for pediatric multidrug-resistant tuberculosis. Practice-based recommendations
EP Harausz, AJ Garcia-Prats, JA Seddon… - American journal of …, 2017 - atsjournals.org
It is estimated that 33,000 children develop multidrug-resistant tuberculosis (MDR-TB) each
year. In spite of these numbers, children and adolescents have limited access to the new …
year. In spite of these numbers, children and adolescents have limited access to the new …
Pharmacokinetics and safety of moxifloxacin in children with multidrug-resistant tuberculosis
S Thee, AJ Garcia-Prats, HR Draper… - Clinical Infectious …, 2015 - academic.oup.com
Moxifloxacin serum concentrations in children receiving multidrug-resistant tuberculosis
treatment following an oral dose of 10 mg/kg were low. Human immunodeficiency virus infection …
treatment following an oral dose of 10 mg/kg were low. Human immunodeficiency virus infection …
[HTML][HTML] Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data …
…, E Engidawork, AJ Garcia-Prats… - European …, 2023 - Eur Respiratory Soc
Background Suboptimal exposure to antituberculosis (anti-TB) drugs has been associated
with unfavourable treatment outcomes. We aimed to investigate estimates and determinants …
with unfavourable treatment outcomes. We aimed to investigate estimates and determinants …
[HTML][HTML] Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: combined data from two prospective observational …
AJ Garcia-Prats, HS Schaaf, HR Draper… - PLoS …, 2019 - journals.plos.org
Background Linezolid is increasingly important for multidrug-resistant tuberculosis (MDR-TB)
treatment. However, among children with MDR-TB, there are no linezolid pharmacokinetic …
treatment. However, among children with MDR-TB, there are no linezolid pharmacokinetic …
[HTML][HTML] Levofloxacin versus placebo for the prevention of tuberculosis disease in child contacts of multidrug-resistant tuberculosis: study protocol for a phase III cluster …
Background Multidrug-resistant (MDR) tuberculosis (TB) presents a challenge for global TB
control. Treating individuals with MDR-TB infection to prevent progression to disease could …
control. Treating individuals with MDR-TB infection to prevent progression to disease could …
Tuberculosis in children with severe acute malnutrition
…, E Fitzgerald, A Kondwani, AJ Garcia-Prats - Expert review of …, 2022 - Taylor & Francis
Introduction With growing attention globally to the childhood tuberculosis epidemic after
decades of neglect, and with the burden of severe acute malnutrition (SAM) remaining …
decades of neglect, and with the burden of severe acute malnutrition (SAM) remaining …
Levofloxacin population pharmacokinetics in South African children treated for multidrug-resistant tuberculosis
P Denti, AJ Garcia-Prats, HR Draper… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Levofloxacin is increasingly used in the treatment of multidrug-resistant tuberculosis (MDR-TB).
There are limited pediatric pharmacokinetic data to inform dose selection for children. …
There are limited pediatric pharmacokinetic data to inform dose selection for children. …