Extracellular ATP is implicated in numerous sensory processes ranging from the response to
pain to the regulation of motility in visceral organs 1 . The ATP receptor P2X 3 is selectively …

Studies on monozygotic twins with concordant leukemia and retrospective scrutiny of
neonatal blood spots of patients with leukemia indicate that chromosomal translocations …

Identical infant twins with concordant leukemia were first described in 1882, and since that
time many such pairs of infants and older children have been described. It has long been …

Epidemiological evidence has suggested that some pediatric leukemias may be initiated in
utero and, for some pairs of identical twins with concordant leukemia, this possibility has …

The present study explores the possible involvement of a purinergic mechanism in
mechanosensory transduction in the bladder using P2X 3 receptor knock-out (P2X 3 − /− ) and wild-…

THE majority ( ∼ 75%) of infant acute leukaemias have a reciprocal translocation between
chromosome 11q23 and one of several partner chromosomes 1 . The gene at 1lq23 (named …

… at higher exposures than were used in this study (Ford AP, unpublished); therefore, we
required … adverse effects were emesis and reduced food consumption (Ford AP, unpublished). …

Extracellular ATP plays a role in nociceptive signalling and sensory regulation of visceral
function through ionotropic receptors variably composed of P2X 2 and P2X 3 subunits. P2X 2 …

The ETV6-RUNX1 fusion gene, found in 25% of childhood acute lymphoblastic leukemia (ALL)
cases, is acquired in utero but requires additional somatic mutations for overt leukemia. …

Significant progress in understanding the pharmacological characteristics and physiological
importance of homomeric and heteromeric P2X channels has been achieved in recent years…