MicroRNAs are a recently discovered class of posttranscriptional regulators of gene
expression with critical functions in health and disease. Psoriasis is the most prevalent chronic …

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability.
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …

Recent studies identified YidC as a novel membrane factor that may play a key role in
membrane insertion of inner membrane proteins (IMPs), both in conjunction with the Sec-…

Eczema often precedes the development of asthma in a disease course called the ‘atopic
march’. To unravel the genes underlying this characteristic pattern of allergic disease, we …

Posttranslational mechanisms are implicated in the development of epithelial cell polarity,
but little is known about the patterns of gene expression and transcriptional regulation during …

Common genetic variants have been identified for adult height, but not much is known
about the genetics of skeletal growth in early life. To identify common genetic variants that …

Rationale: The evidence supporting an association between traffic-related air pollution
exposure and incident childhood asthma is inconsistent and may depend on genetic factors. …

Antibodies are key reagents in biology and medicine, but commercial sources are rarely
recombinant and thus do not provide a permanent and renewable resource. Here, we describe …

We have characterized the membrane topology of a 60-kDa inner membrane protein from
Escherichia coli that is homologous to the recently identified Oxa1p protein in Saccharomyces …

Background Atopic eczema (AE) is a common chronic inflammatory skin disorder. In order to
dissect the genetic background several linkage and genetic association studies have been …