Despite increasing use of prothrombin complex concentrate (PCC) to treat hemorrhage-associated
coagulopathy, few studies have investigated PCC in trauma, and there is a particular …

The peripheral airway innervation of the lower respiratory tract of mammals is not completely
functionally characterized. Recently, we have shown in rats that precision-cut lung slices (…

Background Platelet-derived growth factor (PDGF)-BB and its receptor PDGFR are highly
expressed in pulmonary hypertension (PH) and mediate proliferation. Recently, we showed …

Background The acute respiratory distress syndrome (ARDS) is a serious disease in critically
ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant …

Introduction Cardiovascular agents are pivotal in the therapy of heart failure. Apart from their
action on ventricular contractility and systemic afterload, they affect pulmonary arteries and …

Introduction The phosphodiesterase-III inhibitor milrinone improves ventricular contractility,
relaxes pulmonary arteries and reduces right ventricular afterload. Thus, it is used to treat …

Background Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor
receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, eg …

Background PDGFR-inhibition by the tyrosine kinase inhibitor (TKI) nintedanib attenuates
the progress of idiopathic pulmonary fibrosis (IPF). However, the effects of PDGF-BB on the …

Introduction Levosimendan is approved for left heart failure and is also used in right heart
failure to reduce right ventricular afterload. Despite the fact that pulmonary arteries (PAs) and …

Background Recently, the IMPRES study revealed that systemic imatinib improves exercise
capacity in patients with advanced pulmonary arterial hypertension. Imatinib blocks the …