In a search for genes that regulate circadian rhythms in mammals, the progeny of mice
treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A …

Background Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell
carcinoma. Although most basal-cell carcinomas are treated surgically, no effective …

In the past 50 y, there has been a decline in average sleep duration and quality, with
adverse consequences on general health. A representative survey of 1,508 American adults …

Abbreviations: ACE angiotensin-converting enzyme; ACP American College of Physicians;
A/D antihistamine/decongestant; ATS American Thoracic Society; BPC bronchoprovocation …

Immunotherapies that block inhibitory checkpoint receptors on T cells have transformed the
clinical care of patients with cancer 1 . However, whether the T cell response to checkpoint …

Background No systemic therapies have been approved for the treatment of advanced
cutaneous squamous-cell carcinoma. This cancer may be responsive to immune therapy, …

As a complementary approach to positional cloning, we used in vivo complementation with
bacterial artificial chromosome (BAC) clones expressed in transgenic mice to identify the …

Understanding complex tissues requires single-cell deconstruction of gene regulation with
precision and scale. Here, we assess the performance of a massively parallel droplet-based …

Objectives: To review relevant literature and present evidence-based guidelines to assist
general and specialist medical practitioners in the evaluation and management of children who …

The circadian rhythms of melatonin and body temperature are set to an earlier hour in women
than in men, even when the women and men maintain nearly identical and consistent …