Despite improvements, lung transplantation remains hampered by both a scarcity of donor
organs and by mortality following primary graft dysfunction (PGD). Since acute respiratory …

Precision-cut lung slices (PCLS) have gained increasing interest as a model to study lung
biology/disease and screening novel therapeutics. In particular, PCLS derived from human …

Since its advent in the 1990′s, ex vivo lung perfusion (EVLP) has been studied and
implemented as a tool to evaluate the quality of a donor organ prior to transplantation. It provides …

Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft
dysfunction, making methods to reduce or remove them highly valuable. The mechanisms …

In severe acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation
(ECMO) is a life‐prolonging treatment, especially among COVID‐19 patients. Evaluation …

Background Primary graft dysfunction (PGD) is still a major complication in patients
undergoing lung transplantation (LTx). Much is unknown about the effect of postoperative …

Introduction In recent years, the field of graft preservation has made considerable strides in
improving outcomes related to solid organ restoration and regeneration. Ex vivo lung …

Lung transplantion (LTx) recipients have low long-term survival and a high incidence of
bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic …

Acute lung injury (ALI) represents an aetiologically diverse form of pulmonary damage. Part
of the assessment and diagnosis of ALI depends on skilled observer-based scoring of …

Mesenchymal stem cells (MSCs) have been studied for their potential benefits in treating
acute respiratory distress syndrome (ARDS) and have reported mild effects when trialed within …