Background Vitamin D was used to treat tuberculosis in the pre-antibiotic era, and its
metabolites induce antimycobacterial immunity in vitro. Clinical trials investigating the effect of …

Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic
antimicrobial responses in vitro. Vitamin D supplementation elevates circulating calcidiol …

Background Many individuals who survive tuberculosis disease face ongoing disability and
elevated mortality risks. However, the impact of post-tuberculosis sequelae is generally …

Tuberculosis is classically divided into states of latent infection and active disease. Using
combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-…

Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human
infection with Mycobacterium tuberculosis is dependent on the ability of the immune response …

The seasonality of infectious disease outbreaks suggests that environmental conditions have
a significant effect on disease risk. One of the major environmental factors that can affect …

Few studies from Africa have described the clinical impact of co-infections on SARS-CoV-2
infection. Here, we investigate the presentation and outcome of SARS-CoV-2 infection in an …

Background Craniosynostosis, the premature fusion of calvarial sutures, is a common
craniofacial abnormality. Causative mutations in more than 10 genes have been identified, …

Vitamin D deficiency has been reported to associate with the impaired development of
antigen-specific responses following vaccination. We aimed to determine whether vitamin D …

The diversity of COVID-19 disease in otherwise healthy people, from seemingly asymptomatic
infection to severe life-threatening disease, is not clearly understood. We passaged a …