Background The level of anticoagulation in response to a fixed-dose regimen of warfarin is
difficult to predict during the initiation of therapy. We prospectively compared the effect of …

Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…

Background Statin treatment and variants in the gene encoding HMG-CoA reductase are
associated with reductions in both the concentration of LDL cholesterol and the risk of coronary …

Background Observational evidence suggests that the use of a genotype-guided dosing
algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon …

Background & Aims We performed a genome-wide association study (GWAS) to identify
genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously …

… de Boer and AH Maitland-van der Zee are responsible for study concept and design, the …
AH Maitland-van der Zee has full access to all the data in the study and takes responsibility …

Background: We investigated causal effect of completed growth, measured by adult height,
on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental …

Objectives : This study sought to investigate the role of secretory phospholipase A 2 (sPLA 2
)-IIA in cardiovascular disease. Background : Higher circulating levels of sPLA 2 -IIA mass …

This study systematically reviewed and quantified the relationship between exposure to
antibiotics during the first 2 years of life and the risk of allergies/atopies including hay fever, …