Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase–TAT

…, S Myo, E Boetticher, J Tong, AY Meliton… - The Journal of …, 2003 - rupress.org
Phosphoinositide 3-kinase (PI3K) is thought to contribute to the pathogenesis of asthma by
effecting the recruitment, activation, and apoptosis of inflammatory cells. We examined the …

Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome

…, RB Hamanaka, R Niğdelioğlu, AY Meliton… - Environmental …, 2018 - Elsevier
Recent studies suggest an association between particulate matter (PM) air pollution and
gastrointestinal (GI) disease. In addition to direct deposition, PM can be indirectly deposited in …

[HTML][HTML] The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

…, H Abdala-Valencia, K Nam, AY Meliton… - The Journal of …, 2021 - Am Soc Clin Investig
Alveolar macrophages orchestrate the response to viral infections. Age-related changes in
these cells may underlie the differential severity of pneumonia in older patients. We …

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

…, M Krause, MJ Oh, CH Kuo, R Nigdelioglu, AY Meliton… - Elife, 2017 - elifesciences.org
10.7554/eLife.25217.001 Hemodynamic forces regulate vascular functions. Disturbed flow (DF)
occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), and …

Oxidative stress contributes to lung injury and barrier dysfunction via microtubule destabilization

E Kratzer, Y Tian, N Sarich, T Wu, A Meliton… - American journal of …, 2012 - atsjournals.org
Oxidative stress is an important part of host innate immune response to foreign pathogens,
such as bacterial LPS, but excessive activation of redox signaling may lead to pathologic …

[HTML][HTML] Transforming growth factor (TGF)-β promotes de novo serine synthesis for collagen production

R Nigdelioglu, RB Hamanaka, AY Meliton… - Journal of Biological …, 2016 - ASBMB
TGF-β promotes excessive collagen deposition in fibrotic diseases such as idiopathic
pulmonary fibrosis (IPF). The amino acid composition of collagen is unique due to its high (33%) …

Glutamine metabolism is required for collagen protein synthesis in lung fibroblasts

…, LJ Witt, Y Tian, GA Gökalp, AY Meliton… - American journal of …, 2019 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is characterized by the transforming growth factor (TGF)-β–dependent
differentiation of lung fibroblasts into myofibroblasts, leading to excessive …

[PDF][PDF] Metformin targets mitochondrial electron transport to reduce air-pollution-induced thrombosis

…, T Cho, RB Hamanaka, AY Meliton… - Cell metabolism, 2019 - cell.com
Urban particulate matter air pollution induces the release of pro-inflammatory cytokines
including interleukin-6 (IL-6) from alveolar macrophages, resulting in an increase in thrombosis. …

Tissue-resident alveolar macrophages do not rely on glycolysis for LPS-induced inflammation

PS Woods, LM Kimmig, AY Meliton, KA Sun… - American journal of …, 2020 - atsjournals.org
Macrophage effector function is dynamic in nature and largely dependent on not only the
type of immunological challenge but also the tissue-specific environment and developmental …

Alterations of lung microbiota in a mouse model of LPS-induced lung injury

V Poroyko, F Meng, A Meliton… - … of Physiology-Lung …, 2015 - journals.physiology.org
Acute lung injury (ALI) and the more severe acute respiratory distress syndrome are common
responses to a variety of infectious and noninfectious insults. We used a mouse model of …