MAMMALIAN C-type retroviruses are inactivated by human serum 1,2 , following triggering of
the classical complement cascade 3 . This may have inhibited transmission to humans of C-…

Suboptimal adherence to maintenance therapy contributes to poor asthma control and
exacerbations. This study evaluated the effect of different elements of a connected inhaler system …

No definitive biologic function has been associated with the human ABO histo-blood group
polymorphism, or any other terminal carbohydrate differences within or between closely …

Background: Two studies were undertaken to characterize the maximal effort inhalation
profiles of healthy subjects and patients with asthma or chronic obstructive pulmonary disease (…

Background Administering maintenance COPD therapy with a combination of multiple inhalers
may increase inhaler errors. This study evaluated the potential benefits of using a single …

Human serum contains natural antibodies (NAb), which can bind to endothelial cell surface
antigens of other mammals. This is believed to be the major initiating event in the process of …

Umeclidinium bromide (GSK573719; UMEC), a new long-acting muscarinic receptor antagonist
(LAMA), is in development with vilanterol (GW642444; VI), a selective long-acting β 2 …

Background The combination of umeclidinium (UMEC), a long-acting muscarinic receptor
antagonist, and vilanterol (VI), a selective long-acting β 2 agonist, is in development for the …

Natural antibodies (NAb) and complement (C’) are important regulators of immune system
activation. We have shown previously that the galactosyl‐α1,3‐galactosyl (Galα1,3Gal) …

To characterise the safety, tolerability, pharmacodynamics (bronchodilatory effect) and
pharmacokinetics of inhaled umeclidinium in patients with chronic obstructive pulmonary disease …