Background Intrapleural fibrinolytic agents are used in the drainage of infected pleural-fluid
collections. This use is based on small trials that did not have the statistical power to …

Background More than 30% of patients with pleural infection either die or require surgery.
Drainage of infected fluid is key to successful treatment, but intrapleural fibrinolytic therapy did …

Background Early-phase and preclinical studies suggest that moxifloxacin-containing regimens
could allow for effective 4-month treatment of uncomplicated, smear-positive pulmonary …

Drugs for tuberculosis are inadequate to address the many inherent and emerging
challenges of treatment. In the past decade, ten compounds have progressed into the clinical …

Background Tuberculosis regimens that are shorter and simpler than the current 6-month
daily regimen are needed. Methods We randomly assigned patients with newly diagnosed, …

About 1·3 million people died of tuberculosis in 2012, despite availability of effective drug
treatment. Barriers to improvements in outcomes include long treatment duration (resulting in …

Background Tuberculosis is usually treated with a 6-month rifampin-based regimen.
Whether a strategy involving shorter initial treatment may lead to similar outcomes is unclear. …

Background Cohort studies in Bangladesh showed promising cure rates among patients with
multidrug-resistant tuberculosis who received existing drugs in regimens shorter than that …

Background The optimal choice of chest tube size for the treatment of pleural infection is
unknown, with only small cohort studies reported describing the efficacy and adverse events of …

Background The therapeutic and economic benefits of continuous positive airway pressure (CPAP)
for moderate to severe obstructive sleep apnoea (OSA) syndrome have been …