Intermittent hypoxia-induced cardiovascular remodeling is reversed by normoxia in a mouse model of sleep apnea

AL Castro-Grattoni, R Alvarez-Buvé, M Torres, R Farré… - Chest, 2016 - Elsevier
… Author links open overlay panel Anabel L. Castro-Grattoni MS a , Roger Alvarez-Buvé MS
a , Marta Torres PhD b d , Ramon Farré PhD c d , Josep M. Montserrat MD, PhD b c d , Mireia …

Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring

AL Castro-Grattoni, G Torres… - European …, 2017 - Eur Respiratory Soc
The reduction in blood pressure (BP) with continuous positive airway pressure (CPAP) is
modest and highly variable. In this study, we identified the variables that predict BP response to …

Management of obstructive sleep apnoea in a primary care vs sleep unit setting: a randomised controlled trial

…, A Juarez, M Gracia, AL Castro-Grattoni, L Pascual… - Thorax, 2018 - thorax.bmj.com
Objective To assess the effectiveness and cost-effectiveness of primary care (PC) and sleep
unit (SU) models for the management of subjects with suspected obstructive sleep apnoea (…

[HTML][HTML] Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP)

…, F Barbé, AL Castro-Grattoni, JM Auguet, L Pascual… - PloS one, 2018 - journals.plos.org
Objectives Obstructive sleep apnea (OSA) is among the least studied risk factors for erectile
dysfunction (ED). We aimed to determine ED prevalence in newly-diagnosed OSA patients, …

Effect of age on the cardiovascular remodelling induced by chronic intermittent hypoxia as a murine model of sleep apnoea

AL CastroGrattoni, M Suarez‐Giron, I Benitez… - …, 2020 - Wiley Online Library
Background and objective Chronic intermittent hypoxia (CIH) is a major determinant of the
cardiovascular morbidity associated with obstructive sleep apnoea (OSA), and the magnitude …

The effect of chronic intermittent hypoxia in cardiovascular gene expression is modulated by age in a mice model of sleep apnea

AL Castro-Grattoni, M Suarez-Giron, I Benitez… - Sleep, 2021 - academic.oup.com
Study Objectives Chronic intermittent hypoxia (CIH) is a major determinant in obstructive
sleep apnea cardiovascular morbidity and this effect is influenced by age. The objective of the …

Cardiovascular morbidities of obstructive sleep apnea and the role of circulating extracellular vesicles

A Khalyfa, AL Castro-Grattoni… - Therapeutic Advances in …, 2019 - journals.sagepub.com
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway collapse during
sleep resulting in impaired blood gas exchange, namely intermittent hypoxia (IH) and …

[HTML][HTML] Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition

…, N Carrillo-López, S Panizo, AL Castro-Grattoni… - Scientific reports, 2019 - nature.com
In chronic kidney disease (CKD), hyperphosphatemia-induced inflammation aggravates
vascular calcification (VC) by increasing vascular smooth muscle cell (VSMC) osteogenic …

[HTML][HTML] GESAP trial rationale and methodology: management of patients with suspected obstructive sleep apnea in primary care units compared to sleep units

…, J de Batlle, N Nadal, AL Castro-Grattoni… - NPJ Primary Care …, 2017 - nature.com
Background Obstructive sleep apnea syndrome (OSA) is a chronic sleep disorder characterized
by repeated episodes of upper airway collapse during sleep. This leads to arterial …

Vitamin D Deficiency Induces Macrophage Pro-Inflammatory Phenotype via ER Stress-Mediated Activation of Renin-Angiotensin System

…, AE Riek, A Dusso, AL Castro-Grattoni… - Journal of the …, 2021 - ncbi.nlm.nih.gov
Chronic inflammation and local activation of the renin-angiotensin-aldosterone system (RAAS)
play a pivotal role in the pathogenesis and progression of diabetic complications. In …