User profiles for Allan Lawrie
 | Allan LawrieImperial College London Verified email at imperial.ac.uk Cited by 9704 |
[PDF][PDF] Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was
introduced in the United Kingdom to accelerate population coverage with a single dose. At this …
introduced in the United Kingdom to accelerate population coverage with a single dose. At this …
[HTML][HTML] Identification of rare sequence variation underlying heritable pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious
variation within components of the transforming growth factor-β pathway, particularly the …
variation within components of the transforming growth factor-β pathway, particularly the …
[HTML][HTML] T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre …
…, S Dobson, S Adlou, T de Silva, A Lawrie… - The Lancet …, 2022 - thelancet.com
Background Previous infection with SARS-CoV-2 affects the immune response to the first
dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and …
dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and …
Pulmonary hypertension in COPD: results from the ASPIRE registry
The phenotype and outcome of severe pulmonary hypertension in chronic obstructive pulmonary
disease (COPD) is described in small numbers, and predictors of survival are unknown…
disease (COPD) is described in small numbers, and predictors of survival are unknown…
[HTML][HTML] MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension
…, SE Francis, DJ Rowlands, A Lawrie - The Journal of …, 2016 - Am Soc Clin Investig
Loss of the growth-suppressive effects of bone morphogenetic protein (BMP) signaling has
been demonstrated to promote pulmonary arterial endothelial cell dysfunction and induce …
been demonstrated to promote pulmonary arterial endothelial cell dysfunction and induce …
Targeting vascular remodeling to treat pulmonary arterial hypertension
AAR Thompson, A Lawrie - Trends in molecular medicine, 2017 - cell.com
Pulmonary arterial hypertension (PAH) describes a group of conditions with a common
hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive …
hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive …
Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension
Rationale: MicroRNAs (miRNAs or miRs) are implicated in the pathogenesis of various
cardiovascular diseases, including pulmonary arterial hypertension (PAH). Objectives: We …
cardiovascular diseases, including pulmonary arterial hypertension (PAH). Objectives: We …
Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro
A Lawrie, AF Brisken, SE Francis, DI Tayler… - Circulation, 1999 - Am Heart Assoc
Background—Restenosis after percutaneous coronary intervention remains a serious
clinical problem. Progress in local gene therapy to prevent restenosis has been hindered by …
clinical problem. Progress in local gene therapy to prevent restenosis has been hindered by …
Zebrafish as a tractable model of human cardiovascular disease
…, E Kugler, R Wilkinson, A Lawrie… - British Journal of …, 2022 - Wiley Online Library
Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an increasing …
extensively to study the mechanisms of cardiovascular disease. However, there is an increasing …
Plasma metabolomics implicates modified transfer RNAs and altered bioenergetics in the outcomes of pulmonary arterial hypertension
Background: Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high
mortality. Methods: We conducted a comprehensive study of plasma metabolites using …
mortality. Methods: We conducted a comprehensive study of plasma metabolites using …