Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia
PY Dumas, A Villacreces, AV Guitart, A El-Habhab… - Clinical Cancer …, 2021 - AACR
Purpose: AXL has been shown to play a pivotal role in the selective response of FLT3-ITD
acute myeloid leukemia (AML) cells to FLT3 tyrosine kinase inhibitors (TKI), particularly within …
acute myeloid leukemia (AML) cells to FLT3 tyrosine kinase inhibitors (TKI), particularly within …
Ageing enhances the shedding of splenocyte microvesicles with endothelial pro-senescent effect that is prevented by a short-term intake of omega-3 PUFA EPA: DHA …
AW Qureshi, R Altamimy, A El Habhab, H El Itawi… - Biochemical …, 2020 - Elsevier
Background Ageing is associated with progressive endothelial senescence and dysfunction,
and cardiovascular risk. Circulating endothelial microvesicles (MVs) are pro-senescent and …
and cardiovascular risk. Circulating endothelial microvesicles (MVs) are pro-senescent and …
Significance of neutrophil microparticles in ischaemia‐reperfusion: pro‐inflammatory effectors of endothelial senescence and vascular dysfunction
A El Habhab, R Altamimy, M Abbas… - Journal of Cellular …, 2020 - Wiley Online Library
Endothelial senescence is an emerging cause of vascular dysfunction. Because
microparticles are effectors of endothelial inflammation and vascular injury after ischaemia‐reperfusion, …
microparticles are effectors of endothelial inflammation and vascular injury after ischaemia‐reperfusion, …
[HTML][HTML] Autophagy targeting and hematological mobilization in FLT3-ITD acute myeloid leukemia decrease repopulating capacity and relapse by inducing apoptosis …
…, A Villacreces, I Vigon, V Desplat, A El Habhab… - Cancers, 2022 - mdpi.com
Simple Summary One of the most frequent molecular anomalies in acute myeloid leukemia (AML)
is the mutation of the fms-like receptor tyrosine kinase 3 through internal tandem …
is the mutation of the fms-like receptor tyrosine kinase 3 through internal tandem …
Endothelial microparticles released by activated protein C protect beta cells through EPCR/PAR1 and annexin A1/FPR2 pathways in islets
G Kreutter, M Kassem, A El Habhab… - Journal of cellular …, 2017 - Wiley Online Library
Islet transplantation is associated with early ischaemia/reperfusion, localized coagulation and
redox‐sensitive endothelial dysfunction. In animal models, islet cytoprotection by activated …
redox‐sensitive endothelial dysfunction. In animal models, islet cytoprotection by activated …
Epithelial-mesenchymal transition and membrane microparticles: potential implications for bronchiolitis obliterans syndrome after lung transplantation
…, A El-Habhab, M Kassem, F El-Ghazouani… - Transplant …, 2020 - Elsevier
Long term survival post lung transplantation (LTx) is limited by the occurrence of
bronchiolitis obliterans syndrome (BOS). One mechanism involved is the epithelial-mesenchymal …
bronchiolitis obliterans syndrome (BOS). One mechanism involved is the epithelial-mesenchymal …
Senescence of pancreas in middle-aged rats with normal vascular function
…, ZR Niazi, M Abbas, A El Habhab… - Annals of …, 2017 - medscimonit.com
BACKGROUND: In organ transplantation, particularly pancreas transplantation, donor age
is a determinant factor for graft survival. Physiological aging is crucial in the progressive …
is a determinant factor for graft survival. Physiological aging is crucial in the progressive …
Visual outcomes after cataract surgery in monocular compared to binocular patients: a case–control study
O Dabbur, E Koestel, A El Habhab, T Ahmad… - International …, 2024 - Springer
Purpose We aimed to identify ocular comorbidities and reasons of blindness in monocular
patients and to compare visual outcomes of cataract surgery between monocular and …
patients and to compare visual outcomes of cataract surgery between monocular and …
[HTML][HTML] Assessment of plasma microvesicles to monitor pancreatic islet graft dysfunction: Beta cell-and leukocyte-derived microvesicles as specific features in a pilot …
…, FZ El-Ghazouani, M Kassem, A El Habhab… - American Journal of …, 2020 - Elsevier
Markers of early pancreatic islet graft dysfunction and its causes are lacking. We monitored
19 type 1 diabetes islet-transplanted patients for up to 36 months following last islet injection. …
19 type 1 diabetes islet-transplanted patients for up to 36 months following last islet injection. …
In vitro impact of pro-senescent endothelial microvesicles on isolated pancreatic rat islets function
M Kassem, A El Habhab, G Kreutter, L Amoura… - Transplantation …, 2021 - Elsevier
… Author links open overlay panel Mohamad Kassem a , Ali El Habhab a , Guillaume Kreutter
a , Lamia Amoura a , Philippe Baltzinger b , Malak Abbas c , Noura Sbat a , Fatiha Zobairi a , …
a , Lamia Amoura a , Philippe Baltzinger b , Malak Abbas c , Noura Sbat a , Fatiha Zobairi a , …