Distinct brainstem and forebrain circuits receiving tracheal sensory neuron inputs revealed using a novel conditional anterograde transsynaptic viral tracing system
AE McGovern, AK Driessen, DG Simmons… - Journal of …, 2015 - Soc Neuroscience
Sensory nerves innervating the mucosa of the airways monitor the local environment for the
presence of irritant stimuli and, when activated, provide input to the nucleus of the solitary …
presence of irritant stimuli and, when activated, provide input to the nucleus of the solitary …
Central mechanisms of airway sensation and cough hypersensitivity
AK Driessen, AE McGovern, M Narula, SK Yang… - Pulmonary …, 2017 - Elsevier
The airway sensory nervous system is composed of two anatomically distinct processing
pathways that allow for the production of respiratory reflexes and voluntary evoked respiratory …
pathways that allow for the production of respiratory reflexes and voluntary evoked respiratory …
Multiple neural circuits mediating airway sensations: recent advances in the neurobiology of the urge-to-cough
AK Driessen, MJ Farrell, SB Mazzone… - Respiratory physiology & …, 2016 - Elsevier
The respiratory system is densely innervated by sensory neurons arising from the jugular (superior)
and nodose (inferior) vagal ganglia. However, a distinction exists between jugular …
and nodose (inferior) vagal ganglia. However, a distinction exists between jugular …
[HTML][HTML] The role of the paratrigeminal nucleus in vagal afferent evoked respiratory reflexes: a neuroanatomical and functional study in guinea pigs
AK Driessen, MJ Farrell, SB Mazzone… - Frontiers in …, 2015 - frontiersin.org
The respiratory tree receives sensory innervation from the jugular and nodose vagal sensory
ganglia. Neurons of these ganglia are derived from embryologically distinct origins and as …
ganglia. Neurons of these ganglia are derived from embryologically distinct origins and as …
[HTML][HTML] Peripheral and central mechanisms of cough hypersensitivity
N Singh, AK Driessen, AE McGovern… - Journal of Thoracic …, 2020 - ncbi.nlm.nih.gov
Chronic cough is a difficult to treat symptom of many respiratory and some non-respiratory
diseases, indicating that varied pathologies can underpin the development of chronic cough. …
diseases, indicating that varied pathologies can underpin the development of chronic cough. …
A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin‐evoked cough in guinea‐pigs
AK Driessen, AE McGovern, R Behrens… - The Journal of …, 2020 - Wiley Online Library
Key points Airway projecting sensory neurons arising from the jugular vagal ganglia terminate
centrally in the brainstem paratrigeminal nucleus, synapsing upon neurons expressing …
centrally in the brainstem paratrigeminal nucleus, synapsing upon neurons expressing …
[HTML][HTML] Vagal afferent processing by the paratrigeminal nucleus
AK Driessen - Frontiers in physiology, 2019 - frontiersin.org
The paratrigeminal nucleus is an obscure region in the dorsal lateral medulla, which has
been best characterized as a collection of interstitial cells located in the dorsal tip of the spinal …
been best characterized as a collection of interstitial cells located in the dorsal tip of the spinal …
Reflex regulation of breathing by the paratrigeminal nucleus via multiple bulbar circuits
AK Driessen, MJ Farrell, M Dutschmann… - Brain Structure and …, 2018 - Springer
Sensory neurons of the jugular vagal ganglia innervate the respiratory tract and project to
the poorly studied medullary paratrigeminal nucleus. In the present study, we used …
the poorly studied medullary paratrigeminal nucleus. In the present study, we used …
Hippocampal modulation of cardiorespiratory function
IE Ajayi, AE McGovern, AK Driessen, NF Kerr… - Respiratory physiology …, 2018 - Elsevier
Abstract Changes in cardiorespiratory control accompany the expression of complex emotions,
indicative of limbic brain inputs onto bulbar autonomic pathways. Previous studies have …
indicative of limbic brain inputs onto bulbar autonomic pathways. Previous studies have …
Perspectives on neuroinflammation contributing to chronic cough
AK Driessen, AC Devlin, FT Lundy… - European …, 2020 - Eur Respiratory Soc
Chronic cough can be a troublesome clinical problem. Current thinking is that increased
activity and/or enhanced sensitivity of the peripheral and central neural pathways mediates …
activity and/or enhanced sensitivity of the peripheral and central neural pathways mediates …