User profiles for Alexander V. Misharin

Alexander Misharin

Northwestern University
Verified email at northwestern.edu
Cited by 15950

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

…, CJ Gottardi, GRS Budinger, AV Misharin - American journal of …, 2019 - atsjournals.org
Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes …

[HTML][HTML] Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

…, A Bharat, CJ Gottardi, GRS Budinger, AV Misharin… - Nature, 2021 - nature.com
Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
develop severe pneumonia and acute respiratory distress syndrome 1 (ARDS). Distinct …

Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung

AV Misharin, L Morales-Nebreda, GM Mutlu… - American journal of …, 2013 - atsjournals.org
The lung hosts multiple populations of macrophages and dendritic cells, which play a crucial
role in lung pathology. The accurate identification and enumeration of these subsets are …

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

AV Misharin, L Morales-Nebreda… - Journal of Experimental …, 2017 - rupress.org
Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte-…

Lung transplantation for patients with severe COVID-19

…, AV Yeldandi, JW Lomasney, AV Misharin… - Science translational …, 2020 - science.org
Lung transplantation can potentially be a life-saving treatment for patients with nonresolving
COVID-19–associated respiratory failure. Concerns limiting lung transplantation include …

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

…, Q Ma, Y Takahashi, AR Woodfin, AV Misharin… - Nature medicine, 2017 - nature.com
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor
characterized by rapid and uniform patient demise 1 . A heterozygous point mutation of histone …

[HTML][HTML] An integrated cell atlas of the lung in health and disease

…, PR Tata, JL Schultze, SA Teichmann, AV Misharin… - Nature Medicine, 2023 - nature.com
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …

[HTML][HTML] Mapping single-cell data to reference atlases by transfer learning

…, N Yosef, M Interlandi, S Rybakov, AV Misharin… - Nature …, 2022 - nature.com
Large single-cell atlases are now routinely generated to serve as references for analysis of
smaller-scale studies. Yet learning from reference data is complicated by batch effects …

[HTML][HTML] The role of macrophages in the resolution of inflammation

S Watanabe, M Alexander, AV Misharin… - The Journal of …, 2019 - Am Soc Clin Investig
Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal
tissue development, homeostasis, and repair of damaged tissue. Macrophage function is …

[HTML][HTML] Local and systemic responses to SARS-CoV-2 infection in children and adults

…, C Jolly, P De Coppi, CM Smith, AV Misharin… - Nature, 2022 - nature.com
It is not fully understood why COVID-19 is typically milder in children 1 , 2 – 3 . Here, to examine
the differences between children and adults in their response to SARS-CoV-2 infection, …