Asthma-like symptoms, methacholine hyperresponsiveness, and use of asthma medication
are prevalent in elite cross-country skiers. We quantitated mucosal inflammatory cell …

Tenascin and fibronectin are extracellular matrix glycoproteins expressed during
morphogenesis and tissue repair. In the present study bronchial biopsies were studied by the …

Background Purified α1 proteinase inhibitor (A1PI) slowed emphysema progression in patients
with severe α1 antitrypsin deficiency in a randomised controlled trial (RAPID-RCT), which …

Background Clinicians are increasingly recognizing severe asthma patients in whom biologics
and other add-on therapies lead to dramatic improvement. Currently, there is no agreed-…

Background Phenotypic characteristics of patients with eosinophilic and noneosinophilic
asthma are not well characterized in global, real-life severe asthma cohorts. Research …

Observation of bronchus-associated lymphoid tissue (BALT) in whole lung specimens from
healthy nonsmoking adults has questioned the hypothesis that BALT is not constitutively …

Background Regulatory bodies have approved five biologics for severe asthma. However,
regional differences in accessibility may limit the global potential for personalized medicine. …

BACKGROUND Effectiveness of biologics has neither been established in patients with high
oral corticosteroid exposure (HOCS), nor been compared to effectiveness of continuing with …

Laminins (Ln) are crucial in airway morphogenesis. Because they are able to interact with
inflammatory cells, they are likely to participate in inflammation accompanied by airway …

Regional and/or national severe asthma registries provide valuable country-specific information.
However, they are often limited in scope within the broader definitions of severe asthma…