Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma
targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction …

Background Asthma is a heterogeneous disease with differences in onset, severity, and
inflammation. Bronchial epithelial cells (BECs) contribute to asthma pathophysiology. Objective …

Background: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma
targeting airway smooth muscle (ASM) with radiofrequent energy. Although implemented …

Background High-resolution computed tomography has limitations in the assessment of
airway wall layers and related remodeling in obstructive lung diseases. Near infrared-based …

Remodeling of tissue, such as airway smooth muscle (ASM) and extracellular matrix, is
considered a key feature of airways disease. No clinically accepted diagnostic method is …

To further substantiate that PS-OCT imaging is able to visualize and quantify ASM content,
we investigated if PS-OCT imaging was able to detect a decrease in ASM content after BT in …

Background: Initial evaluation of the hypothalamus–pituitary–thyroid axis is done by measuring
serum free thyroxine (fT4) and thyrotropin concentrations. For correct interpretation of …

Background Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma, of
which the working mechanism and responder profile are partly unknown. The aim of this …

Background Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma
using radiofrequency energy to target airway remodeling including smooth muscle. The …

Background Airway remodeling is a prominent feature of asthma, which involves increased
airway smooth muscle mass and altered extracellular matrix composition. Bronchial …