Genetic studies of body mass index yield new insights for obesity biology

…, C Hengstenberg, O Holmen, JJ Hottenga, AL James… - Nature, 2015 - nature.com
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Defining the role of common variation in the genomic and biological architecture of adult human height

…, JJ Houwing-Duistermaat, T Illig, A Isaacs, AL James… - Nature …, 2014 - nature.com
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

New genetic loci link adipose and insulin biology to body fat distribution

…, O Holmen, SC Hunt, A Isaacs, T Ittermann, AL James… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

The mechanics of airway narrowing in asthma

AL James, PD Paré, JC Hogg - Am Rev Respir Dis, 1989 - atsjournals.org
This study was designed to determine the potential importance of airway wall thickening in
the pathogenesis of the excess airways narrowing of asthma. The airways in postmortem …

Genome-wide association study identifies five loci associated with lung function

…, ĊT Naluai, AC Olin, K Torén, MN Cooper, AL James… - Nature …, 2010 - nature.com
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

…, I Miljkovic, Y Liu, M Atalay, W Kiess, AL James… - Nature …, 2012 - nature.com
Through genome-wide association meta-analyses of up to 133,010 individuals of European
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo …

…, JW Upham, PN Reynolds, S Hodge, AL James… - The Lancet, 2017 - thelancet.com
Background Exacerbations of asthma cause a substantial global illness burden. Adults with
uncontrolled persistent asthma despite maintenance treatment require additional therapy. …

Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking

AL James, LJ Palmer, E Kicic, PS Maxwell… - American journal of …, 2005 - atsjournals.org
Asthma in adults may be associated with chronic airflow obstruction, possibly resulting from
airway disease in early life and/or a greater rate of decline in lung function in adult life …

[PDF][PDF] Instrumentation and technologies in endoscopic ear surgery

M Badr-El-Dine, AL James… - … Clinics of North …, 2013 - sydneyearendoscopy.com
… Badr-El-Dine M, El-Garem HF, Talaat AM, et al. Endoscopically assisted minimally
invasive microvascular decompression of hemifacial spasm. Otol Neurotol 2002; 23:122–8 …

[PDF][PDF] Endoscopic middle ear surgery in children

AL James - Otolaryngologic Clinics of North America, 2013 - sydneyearendoscopy.com
… Kanotra SP, James AL. The role of endoscopy in pediatric cholesteatoma. In: Society for Ear
James AL. Approaches to cholesteatoma with an intact ossicular chain: Combined use of …