Recent advances in the field of carrier-mediated intestinal absorption of of amino acids,
oligopeptides, monosaccharides, monocarboxylic acids, phosphate, bile acids and several water…

Drug distribution into the brain is strictly regulated by the presence of the blood–brain barrier
(BBB) that is formed by brain capillary endothelial cells. Since the endothelial cells are …

Clinical skills laboratories have been established in medical institutions as facilities for
simulation-based medical education (SBME). SBME is believed to be superior to the traditional …

The number of deaths from colorectal cancer in Japan continues to increase. Colorectal
cancer deaths exceeded 50,000 in 2016. In the 2019 edition, revision of all aspects of …

Primary carnitine deficiency, because of a defect of the tissue plasma membrane carnitine
transporters, causes critical symptoms. However, the transporter has not been molecularly …

We identified three novel transporters structurally belonging to the organic anion transporting
polypeptide (OATP) family in humans. Since previously known rat oatp1 to 3 do not …

Japanese mortality due to colorectal cancer is on the rise, surpassing 49,000 in 2015. Many
new treatment methods have been developed during recent decades. The Japanese …

Background We evaluated the efficacy and safety of S-1 plus oxaliplatin (SOX) as an alternative
to cisplatin plus S-1 (CS) in first-line chemotherapy for advanced gastric cancer (AGC). …

Comprehensive genomic profiling enables genomic biomarker detection in advanced solid
tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we …

A number of proteins are known to be involved in apical/basolateral transport of proteins in
polarized epithelial cells 1 , 2 , 3 , 4 , 5 , 6 , 7 . The small GTP-binding protein Rab8 was …