[HTML][HTML] Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

…, EM Harrison, A Shikotra, A Singapuri… - The Lancet …, 2021 - thelancet.com
Background The impact of COVID-19 on physical and mental health and employment after
hospitalisation with acute disease is not well understood. The aim of this study was to …

[HTML][HTML] Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization

…, O Elneima, HJC McAuley, A Shikotra, A Singapuri… - Nature medicine, 2023 - nature.com
Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective
and subjective components. They are common and debilitating, and can affect the ability to …

Genome-wide association study to identify genetic determinants of severe asthma

…, R Chaudhuri, CE Brightling, M Bafadhel, A Singapuri… - Thorax, 2012 - thorax.bmj.com
Background The genetic basis for developing asthma has been extensively studied. However,
association studies to date have mostly focused on mild to moderate disease and genetic …

Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma

…, S Shah, S Gupta, M Bafadhel, A Singapuri… - American journal of …, 2013 - atsjournals.org
Rationale: The relationship between airway inflammation and obesity in severe asthma is
poorly understood. Objectives: We sought to determine the relationship between sputum …

Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors

…, D Tuteja, RKP Mateo, A Singapuri… - Proceedings of the …, 2006 - National Acad Sciences
Sustained cardiac hypertrophy represents one of the most common causes leading to
cardiac failure. There is emerging evidence to implicate the involvement of NF-κB in the …

[HTML][HTML] Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective …

…, HJC McAuley, A Shikotra, A Singapuri… - The Lancet …, 2022 - thelancet.com
Background No effective pharmacological or non-pharmacological interventions exist for
patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for …

Residual lung abnormalities after COVID-19 hospitalization: interim analysis of the UKILD post–COVID-19 study

…, A Shikotra, AJ Simpson, A Singapuri… - American journal of …, 2023 - atsjournals.org
Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19)
and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…

Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group …

S Gonem, R Berair, A Singapuri, R Hartley… - The Lancet …, 2016 - thelancet.com
Background Eosinophilic airway inflammation is often present in asthma, and reduction of
such inflammation results in improved clinical outcomes. We hypothesised that fevipiprant (…

[HTML][HTML] Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients

S Gupta, R Hartley, UT Khan, A Singapuri… - Journal of allergy and …, 2014 - Elsevier
Background Asthma heterogeneity is multidimensional and requires additional tools to unravel
its complexity. Computed tomography (CT)–assessed proximal airway remodeling and …

Lung computational models and the role of the small airways in asthma

…, M Richardson, A Bell, A Singapuri… - American journal of …, 2019 - atsjournals.org
Rationale: Asthma is characterized by disease within the small airways. Several studies have
suggested that forced oscillation technique–derived resistance at 5 Hz (R5) − resistance at …