[HTML][HTML] Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
…, EM Harrison, A Shikotra, A Singapuri… - The Lancet …, 2021 - thelancet.com
Background The impact of COVID-19 on physical and mental health and employment after
hospitalisation with acute disease is not well understood. The aim of this study was to …
hospitalisation with acute disease is not well understood. The aim of this study was to …
[HTML][HTML] Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
…, O Elneima, HJC McAuley, A Shikotra, A Singapuri… - Nature medicine, 2023 - nature.com
Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective
and subjective components. They are common and debilitating, and can affect the ability to …
and subjective components. They are common and debilitating, and can affect the ability to …
Genome-wide association study to identify genetic determinants of severe asthma
Background The genetic basis for developing asthma has been extensively studied. However,
association studies to date have mostly focused on mild to moderate disease and genetic …
association studies to date have mostly focused on mild to moderate disease and genetic …
Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma
Rationale: The relationship between airway inflammation and obesity in severe asthma is
poorly understood. Objectives: We sought to determine the relationship between sputum …
poorly understood. Objectives: We sought to determine the relationship between sputum …
Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors
…, D Tuteja, RKP Mateo, A Singapuri… - Proceedings of the …, 2006 - National Acad Sciences
Sustained cardiac hypertrophy represents one of the most common causes leading to
cardiac failure. There is emerging evidence to implicate the involvement of NF-κB in the …
cardiac failure. There is emerging evidence to implicate the involvement of NF-κB in the …
[HTML][HTML] Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective …
…, HJC McAuley, A Shikotra, A Singapuri… - The Lancet …, 2022 - thelancet.com
Background No effective pharmacological or non-pharmacological interventions exist for
patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for …
patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for …
Residual lung abnormalities after COVID-19 hospitalization: interim analysis of the UKILD post–COVID-19 study
…, A Shikotra, AJ Simpson, A Singapuri… - American journal of …, 2023 - atsjournals.org
Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19)
and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…
and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…
Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group …
Background Eosinophilic airway inflammation is often present in asthma, and reduction of
such inflammation results in improved clinical outcomes. We hypothesised that fevipiprant (…
such inflammation results in improved clinical outcomes. We hypothesised that fevipiprant (…
[HTML][HTML] Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients
Background Asthma heterogeneity is multidimensional and requires additional tools to unravel
its complexity. Computed tomography (CT)–assessed proximal airway remodeling and …
its complexity. Computed tomography (CT)–assessed proximal airway remodeling and …
Lung computational models and the role of the small airways in asthma
…, M Richardson, A Bell, A Singapuri… - American journal of …, 2019 - atsjournals.org
Rationale: Asthma is characterized by disease within the small airways. Several studies have
suggested that forced oscillation technique–derived resistance at 5 Hz (R5) − resistance at …
suggested that forced oscillation technique–derived resistance at 5 Hz (R5) − resistance at …