Imlifidase is a cysteine proteinase which specifically cleaves IgG, inhibiting Fc-mediated
effector function within hours of administration. Imlifidase converts a positive crossmatch to a …

IdeS is a streptococcal protease that cleaves IgG antibodies into F(ab’) 2 and Fc fragments
with a unique degree of specificity, thereby providing a novel treatment opportunity of IgG-…

We addressed the question of whether the prolonged local retention of the glucocorticoid (GC)
budesonide (BUD) within airway tissue, due to reversible fatty acid esterification, is …

Populations of paddlefish Polyodon spathula have been adversely affected by dams that can
block their movements. Unlike high-head dams that preclude fish passage (unless they are …

Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and evaluated for
treatment of autoimmune disorders. The compounds were tested in mice for their inhibitory …

A new orally active drug, laquinimod (ABR-215062), was shown to completely inhibit the
development of murine acute experimental autoimmune encephalomyelitis (EAE). Furthermore, …

Ag binding to the BCR is a critical step in B cell development and activation, initiating a
cascade of signaling events ultimately leading to proliferation, differentiation, or cell death. A …

We used radio telemetry to evaluate the movement and habitat use of paddlefish Polyodon
spathula in the upper Mississippi River and two tributary rivers. Radio transmitters were …

Background. Highly HLA sensitized patients have limited access to life-saving kidney
transplantation because of a paucity of immunologically suitable donors. Imlifidase is a cysteine …

Background. Imlifidase is an immunoglobulin G (IgG)-specific protease conditionally approved
in the EU for desensitization in highly sensitized crossmatch positive kidney transplant …