Rationale: Mechanisms of coronary occlusion in ST-elevation acute coronary syndrome are
poorly understood. We have previously reported that neutrophil (polymorphonuclear cells […

Background— The underlying pathophysiology of heart failure with preserved ejection fraction
(HFPEF) is incompletely understood, but myocardial extracellular matrix accumulation is …

Leukocyte-mediated inflammation is central in atherothrombosis and ST-segment elevation
myocardial infarction (STEMI). Neutrophil extracellular traps (NETs) have been shown to …

Objective— Restoration of patency is a natural target of vascular remodeling after venous
thrombosis that involves vascular endothelial cells and smooth muscle cells, as well as …

Heart-type fatty acid-binding protein (H-FABP) is a reliable marker of myocardial injury and
was recently identified as a predictor of outcome in acute pulmonary embolism. The aim of …

Pulmonary arterial hypertension is a severe and progressive disease characterized by a
pulmonary vascular remodeling process with expansion of collateral endothelial cells and total …

In cardiac amyloidosis (CA), extracellular deposition of amyloid fibrils within the myocardium
significantly expands the extracellular volume (ECV). Affected patients develop severe …

Membrane-bound plasmin is used by immune cells to degrade extracellular matrices, which
facilitates migration. The plasminogen receptor Plg-R KT is expressed by immune cells, …

Background Chronic thromboembolic pulmonary hypertension (CTEPH) results from persistent
pulmonary vascular obstructions, presumably due to inflammatory thrombosis. Because …

Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of abdominal
aortic aneurysms (AAAs). This study has addressed the notion that NET components might …