Prime-boost vectored malaria vaccines: progress and prospects
…, A Reyes-Sandoval, G O'Hara, K Ewer, A Lawrie… - Human …, 2010 - Taylor & Francis
The difficulty of inducing protective immunity through antibodies against sporozoites led to
efforts to assess vectored vaccines as a means of inducing protective T cell immunity against …
efforts to assess vectored vaccines as a means of inducing protective T cell immunity against …
Targeting vascular remodeling to treat pulmonary arterial hypertension
AAR Thompson, A Lawrie - Trends in molecular medicine, 2017 - cell.com
Pulmonary arterial hypertension (PAH) describes a group of conditions with a common
hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive …
hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive …
[HTML][HTML] MicroRNAs as novel biomarkers for breast cancer
Breast cancer is a complex phenotypically diverse genetic disease, involving a variety of
changes in gene expression and structure. Recent advances in molecular profiling technology …
changes in gene expression and structure. Recent advances in molecular profiling technology …
[HTML][HTML] Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South …
…, S Kerridge, A Koen, G Kwatra, R Lazarus, AM Lawrie… - The Lancet, 2021 - thelancet.com
Background A safe and efficacious vaccine against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of …
coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of …
[PDF][PDF] Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was
introduced in the United Kingdom to accelerate population coverage with a single dose. At this …
introduced in the United Kingdom to accelerate population coverage with a single dose. At this …
Circulating microRNAs as novel minimally invasive biomarkers for breast cancer
Objective: The development of clinically validated biomarkers for cancer has remained an
insurmountable task despite other advances in the field of cancer molecular biology. Mi (cro) …
insurmountable task despite other advances in the field of cancer molecular biology. Mi (cro) …
[HTML][HTML] Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind …
Background Older adults (aged ≥70 years) are at increased risk of severe disease and
death if they develop COVID-19 and are therefore a priority for immunisation should an …
death if they develop COVID-19 and are therefore a priority for immunisation should an …
[HTML][HTML] Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials …
…, S Koleva, J Kwok, CW Larkworthy, AM Lawrie… - The Lancet, 2021 - thelancet.com
Background COVID-19 vaccine supply shortages are causing concerns about compromised
immunity in some countries as the interval between the first and second dose becomes …
immunity in some countries as the interval between the first and second dose becomes …
Microbubble-enhanced ultrasound for vascular gene delivery
A Lawrie, AF Brisken, SE Francis, DC Cumberland… - Gene therapy, 2000 - nature.com
Progress in cardiovascular gene therapy has been hampered by concerns over the safety
and practicality of viral vectors and the inefficiency of current nonviral transfection techniques. …
and practicality of viral vectors and the inefficiency of current nonviral transfection techniques. …
Local and global cytosolic Ca2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphate
P Thorn, AM Lawrie, PM Smith, DV Gallacher… - Cell, 1993 - cell.com
Submaximal stimulation with agonists generating inositol 1, 4&trisphosphate(IPa) evokes
cytosolic Ca2+ oscillations in many different cell types. In general, each Ca2+ rise is initiated …
cytosolic Ca2+ oscillations in many different cell types. In general, each Ca2+ rise is initiated …