User profiles for A. Lawrie

Aoife Lowery

- Verified email at nuigalway.ie - Cited by 9758

Allan Lawrie

- Verified email at imperial.ac.uk - Cited by 9609

Prime-boost vectored malaria vaccines: progress and prospects

…, A Reyes-Sandoval, G O'Hara, K Ewer, A Lawrie… - Human …, 2010 - Taylor & Francis
The difficulty of inducing protective immunity through antibodies against sporozoites led to
efforts to assess vectored vaccines as a means of inducing protective T cell immunity against …

Targeting vascular remodeling to treat pulmonary arterial hypertension

AAR Thompson, A Lawrie - Trends in molecular medicine, 2017 - cell.com
Pulmonary arterial hypertension (PAH) describes a group of conditions with a common
hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive …

[HTML][HTML] MicroRNAs as novel biomarkers for breast cancer

HM Heneghan, N Miller, AJ Lowery, KJ Sweeney… - Journal of …, 2009 - hindawi.com
Breast cancer is a complex phenotypically diverse genetic disease, involving a variety of
changes in gene expression and structure. Recent advances in molecular profiling technology …

[HTML][HTML] Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South …

…, S Kerridge, A Koen, G Kwatra, R Lazarus, AM Lawrie… - The Lancet, 2021 - thelancet.com
Background A safe and efficacious vaccine against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of …

[PDF][PDF] Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

…, M Kasanyinga, S Kelly, R Kirk, ML Knight, A Lawrie… - Cell, 2021 - cell.com
Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was
introduced in the United Kingdom to accelerate population coverage with a single dose. At this …

Circulating microRNAs as novel minimally invasive biomarkers for breast cancer

HM Heneghan, N Miller, AJ Lowery… - Annals of …, 2010 - journals.lww.com
Objective: The development of clinically validated biomarkers for cancer has remained an
insurmountable task despite other advances in the field of cancer molecular biology. Mi (cro) …

[HTML][HTML] Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind …

…, D Jenkin, CCD Joe, EJ Kelly, S Kerridge, AM Lawrie… - The Lancet, 2020 - thelancet.com
Background Older adults (aged ≥70 years) are at increased risk of severe disease and
death if they develop COVID-19 and are therefore a priority for immunisation should an …

[HTML][HTML] Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials …

…, S Koleva, J Kwok, CW Larkworthy, AM Lawrie… - The Lancet, 2021 - thelancet.com
Background COVID-19 vaccine supply shortages are causing concerns about compromised
immunity in some countries as the interval between the first and second dose becomes …

Microbubble-enhanced ultrasound for vascular gene delivery

A Lawrie, AF Brisken, SE Francis, DC Cumberland… - Gene therapy, 2000 - nature.com
Progress in cardiovascular gene therapy has been hampered by concerns over the safety
and practicality of viral vectors and the inefficiency of current nonviral transfection techniques. …

Local and global cytosolic Ca2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphate

P Thorn, AM Lawrie, PM Smith, DV Gallacher… - Cell, 1993 - cell.com
Submaximal stimulation with agonists generating inositol 1, 4&trisphosphate(IPa) evokes
cytosolic Ca2+ oscillations in many different cell types. In general, each Ca2+ rise is initiated …