The inactivation of programmed cell death has profound effects not only on the development
but also on the overall integrity of multicellular organisms. Beside developmental …

Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma.
As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected …

Anticholinergics are widely used for the treatment of COPD, and to a lesser extent for asthma.
Primarily used as bronchodilators, they reverse the action of vagally derived acetylcholine …

IL-33, a new member of the IL-1 cytokine family, promotes Th2 inflammation, but evidence
on the implications of this cytokine in asthma is lacking. IL-33 would be mainly expressed by …

… Solway and by grants from Canadian Institutes of Health Research (CIHR) and Canada
Foundation for Innovation to AJ Halayko. AJ Halayko is also a CIHR/Canadian Lung Association …

Airway smooth muscle plays a principal role in the pathogenesis of asthma. Primary cultures
are being used to investigate airway myocyte proliferation and cellular pathways regulating …

Chronic inflammation in asthma and chronic obstructive pulmonary disease drives
pathological structural remodelling of the airways. Using tiotropium bromide, acetylcholine was …

The complex formed by two members of the S100 calcium-binding protein family, S100A8/A9,
exerts apoptosis-inducing activity in various cells of different origins. Here, we present …

Chronic airways diseases, including asthma, are associated with an increased airway
smooth muscle (ASM) mass, which may contribute to chronic airway hyperresponsiveness. …

Transforming growth factor-β 1 (TGF-β 1) is an important regulator of fibrogenesis in heart
disease. In many other cellular systems, TGF-β 1 may also induce autophagy, but a link …