Dilated cardiomyopathy (DCM) frequently affects relatively young, economically, and socially
active adults, and is an important cause of heart failure and transplantation. DCM is a …

In mammals, the heart arises from the differentiation of 2 sources of multipotent
cardiovascular progenitors (MCPs). Different studies indicated that an evolutionary conserved …

Cardiac development arises from two sources of mesoderm progenitors, the first heart field (FHF)
and the second (SHF). Mesp1 has been proposed to mark the most primitive …

Background Cardiac muscle hypercontractility is a key pathophysiological abnormality in
hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow tract (…

CCR5 is a functional receptor for various inflammatory CC-chemokines, including macrophage
inflammatory protein (MIP)-1α and RANTES (regulated on activation normal T cell …

Although it is well recognized that haematopoietic stem cells (HSCs) develop from a
specialized population of endothelial cells known as haemogenic endothelium, the regulatory …

During embryonic development, multipotent cardiovascular progenitor cells are specified
from early mesoderm. Using mouse ESCs in which gene expression can be temporally …

Eosinophil-mediated endomyocardial damage is a well-known complication in patients with
hypereosinophilic syndromes (HES). Although management and survival have improved …

During embryonic development and embryonic stem cell (ESC) differentiation, the different
cell lineages of the mature heart arise from two types of multipotent cardiovascular …

10.7554/eLife.06942.001 We take a functional genomics approach to congenital heart
disease mechanism. We used DamID to establish a robust set of target genes for NKX2-5 wild …