N-glycan profile and kidney disease in type 1 diabetes

…, G Lauc, F Agakov, AS Agakova… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on
circulating glycoproteins, and these alterations may be linked with diabetic kidney disease (…

[HTML][HTML] Glycosylation of plasma IgG in colorectal cancer prognosis

…, M Pučić-Baković, F Vučković, P Orchard, A Agakova… - Scientific reports, 2016 - nature.com
In this study we demonstrate the potential value of Immunoglobulin G (IgG) glycosylation as
a novel prognostic biomarker of colorectal cancer (CRC). We analysed plasma IgG glycans …

[HTML][HTML] Improving prediction of risk of hospital admission in chronic obstructive pulmonary disease: application of machine learning to telemonitoring data

P Orchard, A Agakova, H Pinnock, CD Burton… - Journal of medical …, 2018 - jmir.org
Background Telemonitoring of symptoms and physiological signs has been suggested as a
means of early detection of chronic obstructive pulmonary disease (COPD) exacerbations, …

Automated integration of a UPLC glycomic profile

A Agakova, F Vučković, L Klarić, G Lauc… - … : Methods and Protocols, 2017 - Springer
Ultra-performance liquid chromatography (UPLC) is the established technology for accurate
analysis of IgG Fc N-glycosylation due to its superior sensitivity, resolution, speed, and its …

Learning to care: Using machine learning to improve prediction of COPD admissions

H Pinnock, F Agakov, P Orchard, A Agakova… - 2015 - Eur Respiratory Soc
Background: Telehealth aims to detect imminent exacerbations in order to facilitate prompt
action to prevent admissions. Current algorithms, however, are poor predictors. We aimed to …

Combined action of lithium salts and serotonin on the caudate nucleus

TA Zamoshchina, VP Agakova… - … 'noi Biologii i …, 1985 - europepmc.org
Intracaudate injections of lithium hydroxybutyrate (5 micrograms) produce a serotonin-like
effect on the power characteristics of the caudatogram frequency ranges. However, when …

[HTML][HTML] Heritability of the glycan clock of biological age

A Mijakovac, A Frkatović, M Hanić, J Ivok… - Frontiers in cell and …, 2022 - frontiersin.org
Immunoglobulin G is posttranslationally modified by the addition of complex N-glycans
affecting its function and mediating inflammation at multiple levels. IgG glycome composition …

Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots

J Simunovic, M Vilaj, I Trbojevic-Akmacic… - …, 2019 - academic.oup.com
Immunoglobulin G (IgG) glycans are emerging as a new putative biomarker for biological
age and different diseases, requiring a robust workflow for IgG glycome analysis, ideally …

Plasma N-Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study

C Wittenbecher, T Štambuk, O Kuxhaus… - Diabetes …, 2020 - Am Diabetes Assoc
OBJECTIVE Plasma protein N-glycan profiling integrates information on enzymatic protein
glycosylation, which is a highly controlled ubiquitous posttranslational modification. Here we …

[BOOK][B] High-throughput glycomics and glycoproteomics

G Lauc, M Wuhrer - 2017 - Springer
Carbohydrates—or glycans—are a highly abundant class of biomolecules and can be found
in various shapes and sizes in all kingdoms of life. Glycans often exist in the form of oligoor …