Establishing the validity of different susceptibility testing methods to evaluate the in vitro activity of amoxicillin-clavulanate against Escherichia coli

Diagn Microbiol Infect Dis. 2016 Apr;84(4):334-6. doi: 10.1016/j.diagmicrobio.2015.12.012. Epub 2015 Dec 17.

Abstract

Amoxicillin-clavulanate MICs of 160 Escherichia coli isolates with characterized resistance mechanisms were obtained by 2 MIC gradient strip brands, 3 automated systems, and reference ISO microdilution method using EUCAST (fixed 2μg/mL clavulanate) and CLSI (2:1 ratio) criteria. Discrepancies, mainly obtained with gradient strips, lead to an essential agreement range of 76.2-92.5.

Keywords: Amoxicillin-clavulanate; Automated systems; Escherichia coli; MIC-gradient strips.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Amoxicillin-Potassium Clavulanate Combination / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Escherichia coli / drug effects*
  • Microbial Sensitivity Tests / methods*

Substances

  • Anti-Bacterial Agents
  • Amoxicillin-Potassium Clavulanate Combination