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Nanoblades allow high-level genome editing in murine and human organoids.
Tiroille V, Krug A, Bokobza E, Kahi M, Bulcaen M, Ensinck MM, Geurts MH, Hendriks D, Vermeulen F, Larbret F, Gutierrez-Guerrero A, Chen Y, Van Zundert I, Rocha S, Rios AC, Medaer L, Gijsbers R, Mangeot PE, Clevers H, Carlon MS, Bost F, Verhoeyen E. Tiroille V, et al. Among authors: ensinck mm. Mol Ther Nucleic Acids. 2023 Jun 8;33:57-74. doi: 10.1016/j.omtn.2023.06.004. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37435135 Free PMC article.
Rewriting CFTR to cure cystic fibrosis.
Maule G, Ensinck M, Bulcaen M, Carlon MS. Maule G, et al. Among authors: ensinck m. Prog Mol Biol Transl Sci. 2021;182:185-224. doi: 10.1016/bs.pmbts.2020.12.018. Epub 2021 Jan 28. Prog Mol Biol Transl Sci. 2021. PMID: 34175042 Review.
Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype.
Declercq M, de Zeeuw P, Conchinha NV, Geldhof V, Ramalho AS, García-Caballero M, Brepoels K, Ensinck M, Carlon MS, Bird MJ, Vinckier S, Proesmans M, Vermeulen F, Dupont L, Ghesquière B, Dewerchin M, Carmeliet P, Cassiman D, Treps L, Eelen G, Witters P. Declercq M, et al. Among authors: ensinck m. Eur Respir J. 2021 Apr 22;57(4):2000261. doi: 10.1183/13993003.00261-2020. Print 2021 Apr. Eur Respir J. 2021. PMID: 33184117 Free article.
Severity of the S1251N allele in cystic fibrosis is affected by the presence of the F508C variant in cis.
Cuyx S, Ramalho SS, Callebaut I, Cuppens H, Kmit A, Arnauts K, Ferrante M, Verfaillie C, Ensinck M, Carlon MS, Boon M, Proesmans M, Dupont L, De Boeck K, Farinha CM, Vermeulen F, Ramalho AS. Cuyx S, et al. Among authors: ensinck m. J Cyst Fibros. 2022 Jul;21(4):644-651. doi: 10.1016/j.jcf.2022.05.013. Epub 2022 Jun 9. J Cyst Fibros. 2022. PMID: 35690578