Abstract
Cyanide (CN) is a deadly poison which animals and humans encounter from a number of sources. The following article briefly reviews many of the major studies of CN toxicology in animals and humans. The discussion focuses on sources, body levels, metabolic changes, physiopathology, experimental antidotal studies and the diagnosis and management of CN poisoning in humans.
MeSH terms
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Animals
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Antidotes / administration & dosage
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Antidotes / pharmacology
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Antidotes / therapeutic use
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Catecholamines / blood
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Cats
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Cerebral Cortex / drug effects
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Cyanides / administration & dosage
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Cyanides / pharmacokinetics
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Cyanides / poisoning*
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Dogs
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Electron Transport Complex IV / antagonists & inhibitors
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Energy Metabolism / drug effects
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Female
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Heart / drug effects
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Humans
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Hypoxia / chemically induced
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Male
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Mice
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Poisoning / etiology
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Poisoning / therapy
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Rats
Substances
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Antidotes
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Catecholamines
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Cyanides
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Electron Transport Complex IV