Abstract
The calcium-dependent phosphatidylinositol phosphodiesterase activity of skeletal muscle cytosol was determined. The enzyme was inhibited by Zn2+, Cu2+ and Pb2+ ions but Mg2+ and Mn2+ were without effect. The antimalarial drugs chloroquine and the quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which, like Zn2+, have been shown to block neuromuscular transmission, also inhibited the enzyme.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides / pharmacology
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Animals
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Anti-Bacterial Agents / pharmacology
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Calcium / pharmacology
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Chloroquine / pharmacology
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Humans
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In Vitro Techniques
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Metals / pharmacology*
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Muscles / enzymology*
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Neuromuscular Blocking Agents / pharmacology*
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Phosphatidylinositol Diacylglycerol-Lyase
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Phosphodiesterase Inhibitors*
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Phosphoric Diester Hydrolases
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Quinine / pharmacology
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Metals
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Neuromuscular Blocking Agents
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Phosphodiesterase Inhibitors
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Chloroquine
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Quinine
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Phosphoric Diester Hydrolases
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Phosphatidylinositol Diacylglycerol-Lyase
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Calcium