Extracellular matrix in lung development, homeostasis and disease

Yong Zhou; Jeffrey C Horowitz; Alexandra Naba; Namasivayam Ambalavanan; Kamran Atabai; Jenna Balestrini; Peter B Bitterman; Richard A Corley; Bi-Sen Ding; Adam J Engler; Kirk C Hansen; James S Hagood; Farrah Kheradmand; Qing S Lin; Enid Neptune; Laura Niklason; Luis A Ortiz; William C Parks; Daniel J Tschumperlin; Eric S White; Harold A Chapman; Victor J Thannickal

doi:10.1016/j.matbio.2018.03.005

Extracellular matrix in lung development, homeostasis and disease

Matrix Biol. 2018 Nov:73:77-104. doi: 10.1016/j.matbio.2018.03.005. Epub 2018 Mar 8.

Authors

Yong Zhou¹, Jeffrey C Horowitz², Alexandra Naba³, Namasivayam Ambalavanan⁴, Kamran Atabai⁵, Jenna Balestrini⁶, Peter B Bitterman⁷, Richard A Corley⁸, Bi-Sen Ding⁹, Adam J Engler¹⁰, Kirk C Hansen¹¹, James S Hagood¹², Farrah Kheradmand¹³, Qing S Lin¹⁴, Enid Neptune¹⁵, Laura Niklason¹⁶, Luis A Ortiz¹⁷, William C Parks¹⁸, Daniel J Tschumperlin¹⁹, Eric S White²⁰, Harold A Chapman²¹, Victor J Thannickal²²

Affiliations

¹ Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, United States. Electronic address: yongzhou@uabmc.edu.
² Division of Pulmonary and Critical Care Medicine, University of Michigan, United States. Electronic address: jchorow@med.umich.edu.
³ Department of Physiology & Biophysics, University of Illinois at Chicago, United States. Electronic address: anaba@uic.edu.
⁴ Department of Pediatrics, University of Alabama at Birmingham, United States. Electronic address: nambalavanan@peds.uab.edu.
⁵ Lung Biology Center, University of California, San Francisco, United States. Electronic address: Kamran.Atabai@ucsf.edu.
⁶ Department of Anesthesiology, Yale University, United States. Electronic address: jenna.balestrini@yale.edu.
⁷ Department of Medicine, University of Minnesota, United States. Electronic address: bitte001@umn.edu.
⁸ Systems Toxicology & Exposure Science, Pacific Northwest National Laboratory, United States. Electronic address: rick.corley@pnnl.gov.
⁹ Weill Cornell Medical College, United States. Electronic address: bid2004@med.cornell.edu.
¹⁰ Sanford Consortium for Regenerative Medicine, University of California, San Diego, United States. Electronic address: aengler@eng.ucsd.edu.
¹¹ Biochemistry & Molecular Genetics, University of Colorado Denver, United States. Electronic address: Kirk.Hansen@ucdenver.edu.
¹² Pediatric Respiratory Medicine, University of California San Diego, United States. Electronic address: jhagood@ucsd.edu.
¹³ Division of Pulmonary and Critical Care, Baylor College of Medicine, United States. Electronic address: farrahk@bcm.tmc.edu.
¹⁴ Division of Lung Diseases, National Heart, Lung, and Blood Institute, United States. Electronic address: Sara.lin@nih.gov.
¹⁵ Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, United States. Electronic address: eneptune@jhmi.edu.
¹⁶ Department of Anesthesiology, Yale University, United States. Electronic address: laura.niklason@yale.edu.
¹⁷ Division of Environmental and Occupational Health, University of Pittsburgh, United States. Electronic address: lao1@pitt.edu.
¹⁸ Department of Medicine, Cedars-Sinai Medical Center, United States. Electronic address: bill.parks@cshs.org.
¹⁹ Department of Physiology & Biomedical Engineering, Mayo Clinic College of Medicine, United States. Electronic address: Tschumperlin.Daniel@mayo.edu.
²⁰ Division of Pulmonary and Critical Care Medicine, University of Michigan, United States. Electronic address: docew@med.umich.edu.
²¹ Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, United States. Electronic address: Hal.Chapman@ucsf.edu.
²² Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, United States. Electronic address: vthannickal@uabmc.edu.

Abstract

The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Biomechanical Phenomena
Extracellular Matrix / metabolism
Extracellular Matrix / physiology*
Extracellular Matrix Proteins / metabolism
Homeostasis
Humans
Lung / metabolism*
Lung Diseases / metabolism*
Phenotype

Substances

Extracellular Matrix Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding