A baby girl became ill 2 days after a normal delivery. Streptococcus mitis was isolated from the cerebrospinal fluid, and she recovered uneventfully on treatment with penicillin and, for the first 2 days, netilmicin. The organism was penicillin-tolerant in vitro. Non-groupable alpha-hemolytic streptococci are an uncommon cause of meningitis; three cases have been ascribed to S. mitis.