The search for antiaging interventions: from elixirs to fasting regimens

Rafael de Cabo; Didac Carmona-Gutierrez; Michel Bernier; Michael N Hall; Frank Madeo

doi:10.1016/j.cell.2014.05.031

The search for antiaging interventions: from elixirs to fasting regimens

Cell. 2014 Jun 19;157(7):1515-26. doi: 10.1016/j.cell.2014.05.031.

Authors

Rafael de Cabo¹, Didac Carmona-Gutierrez², Michel Bernier³, Michael N Hall⁴, Frank Madeo⁵

Affiliations

¹ Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. Electronic address: decabora@mail.nih.gov.
² Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria.
³ Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
⁴ Biozentrum, University of Basel, Basel 4056, Switzerland.
⁵ Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria. Electronic address: frank.madeo@uni-graz.at.

Abstract

The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial. Recent evidence is shaping a picture where low caloric regimes and exercise may improve healthy senescence, and several pharmacological strategies have been suggested to counteract aging. Surprisingly, the most effective interventions proposed to date converge on only a few cellular processes, in particular nutrient signaling, mitochondrial efficiency, proteostasis, and autophagy. Here, we critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / drug effects*
Animals
Antioxidants / administration & dosage
Autophagy
Diet
Exercise
Humans
Longevity / drug effects
Signal Transduction

Substances

Antioxidants

Abstract

Publication types

MeSH terms

Substances

Grants and funding