Abstract
Nuclear erythroid factor 2 like 2 (Nrf2) has been described as a transcription factor that serves as a master regulator of the adaptive response to exogenous and endogenous oxidative and electrophilic stresses. Evidence of Nrf2 crosstalk with other molecular pathways is increasing; recent publications have proposed a role of Nrf2 in the development of obesity and in the highly regulated process of adipocyte differentiation through its interaction with other transcription factors and receptors implicated in metabolic regulation. In the present review, we discuss the available data on the possible role of Nrf2 in obesity and metabolic syndrome and the feasibility of using Nrf2 as a therapeutic target in the clinical setting.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / drug effects
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Adaptor Proteins, Signal Transducing / metabolism
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Animals
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Cell Differentiation
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Cytoskeletal Proteins / drug effects
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Cytoskeletal Proteins / metabolism
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Diabetes Mellitus, Type 2 / drug therapy*
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Diabetes Mellitus, Type 2 / physiopathology
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Gene Deletion
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Humans
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Intracellular Signaling Peptides and Proteins / drug effects
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Intracellular Signaling Peptides and Proteins / metabolism*
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Kelch-Like ECH-Associated Protein 1
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Metabolic Syndrome / drug therapy*
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Metabolic Syndrome / physiopathology
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Mice
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Mice, Knockout
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NF-E2-Related Factor 2 / drug effects
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NF-E2-Related Factor 2 / metabolism*
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Oxidative Stress / drug effects
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Receptor Cross-Talk
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Transcription Factors / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Cytoskeletal Proteins
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Intracellular Signaling Peptides and Proteins
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KEAP1 protein, human
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Keap1 protein, mouse
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Kelch-Like ECH-Associated Protein 1
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NF-E2-Related Factor 2
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NFE2L2 protein, human
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Nfe2l2 protein, mouse
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Transcription Factors