Long-term outcome of patients with persistent vascular obstruction on computed tomography pulmonary angiography 6 months after acute pulmonary embolism

Acta Radiol. 2012 Sep 1;53(7):728-31. doi: 10.1258/ar.2012.110697. Epub 2012 Jul 31.

Abstract

Background: The incidence and clinical significance of pulmonary residual thrombosis 6 months after an acute pulmonary embolism (PE) are still not well-known.

Purpose: To evaluate the association between residual vascular obstruction and the risk of venous thromboembolism (VTE) recurrence or death.

Material and methods: Computed tomography pulmonary angiography (CTPA) was repeated in 97 consecutive patients 6 months after an acute episode of hemodynamically stable pulmonary embolism. We assessed the long-term consequences of residual thrombosis on vital status and incidence of recurrent VTE.

Results: Six patients were lost for follow-up. The remaining 91 patients were classified according to the presence (Group 1: 18 cases) or absence (Group 2: 73 cases) of residual pulmonary vascular obstruction. After a mean ± SD of 2.91 ± 0.99 years, there were eight (8.8%) deaths and 11 (12.1%) VTE recurrences. Groups 1 and 2 did not differ in the incidence of death or VTE recurrence.

Conclusion: Persistent pulmonary vascular obstruction on 6-month CTPA did not predict long-term adverse outcome events.

MeSH terms

  • Aged
  • Angiography / methods*
  • Contrast Media
  • Female
  • Humans
  • Incidence
  • Male
  • Pulmonary Embolism / diagnostic imaging*
  • Pulmonary Embolism / etiology
  • Pulmonary Embolism / mortality
  • Pulmonary Embolism / therapy
  • Recurrence
  • Risk Assessment
  • Risk Factors
  • Statistics, Nonparametric
  • Tomography, X-Ray Computed / methods*
  • Treatment Outcome
  • Triiodobenzoic Acids
  • Venous Thromboembolism / complications
  • Venous Thromboembolism / diagnostic imaging*
  • Venous Thromboembolism / mortality
  • Venous Thromboembolism / therapy

Substances

  • Contrast Media
  • Triiodobenzoic Acids
  • ioversol