Myeloid derived suppressor cells in transplantation

Curr Opin Immunol. 2011 Oct;23(5):692-7. doi: 10.1016/j.coi.2011.07.004. Epub 2011 Jul 28.

Abstract

Myeloid derived suppressor cells (MDSC) are a heterogeneous population of hematopoietic derived cell precursors that can suppress immune responses in a variety of inflammatory settings. Here we review recent studies detailing expansion of phenotypically and functionally disparate MDSC. Findings related to MDSC accumulation, activation, and mechanisms utilized in immune suppression are presented. Further, we discuss recent reports that suggest MDSC are expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity*
  • Animals
  • Antigens / immunology
  • Cell Lineage / immunology
  • Cell Proliferation
  • Cytokines / immunology
  • Graft Rejection / immunology
  • Graft Rejection / prevention & control*
  • Humans
  • Immunity, Innate*
  • Immunosuppression Therapy
  • Inflammation / immunology
  • Intercellular Signaling Peptides and Proteins / immunology
  • Mice
  • Mice, Transgenic
  • Myeloid Progenitor Cells* / immunology
  • Myeloid Progenitor Cells* / transplantation
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Organ Transplantation*

Substances

  • Antigens
  • Cytokines
  • Intercellular Signaling Peptides and Proteins