Abstract
We report two cases of drug interaction between rifampicin and sirolimus in renal trans-plant patients who were diagnosed with tuberculosis after transplantation and induction of immuno-suppressive therapy with sirolimus. The dosage of sirolimus had to be increased, in one case up to six-fold and in the second case up to five-fold, to maintain serum levels after starting the rifampicin. The two patients tolerated the treatment well, with no signs of tuberculosis and good renal function.
MeSH terms
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Adult
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Antibiotics, Antitubercular / adverse effects*
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Drug Interactions
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Humans
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Immunosuppressive Agents / adverse effects*
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Immunosuppressive Agents / blood
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Immunosuppressive Agents / pharmacokinetics
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Kidney Transplantation*
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Male
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Middle Aged
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Rifampin / adverse effects*
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Sirolimus / adverse effects*
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Sirolimus / blood
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Sirolimus / pharmacokinetics
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Tuberculosis, Pulmonary / diagnosis
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Tuberculosis, Pulmonary / drug therapy*
Substances
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Antibiotics, Antitubercular
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Immunosuppressive Agents
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Rifampin
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Sirolimus