Inner-city residents continue to suffer disproportionate asthma morbidity despite recent progress in reducing asthma morbidity and mortality in other strata of the United States population. Studies over the past decade indicate that the indoor environment is a strong contributor to poor asthma control and asthma-related health care use in inner-city populations. Certain indoor exposures are more common and occur in higher concentrations in inner-city communities than in suburban communities. Identification of "asthmagenic" indoor exposures has paved the way for the development of intervention strategies aimed at reducing asthma morbidity. This article reviews the growing body of evidence that certain indoor environmental exposures contribute to the burden of asthma in the inner city.