Abstract
Pneumonia, a common disease caused by a great diversity of infectious agents is responsible for enormous morbidity and mortality worldwide. The bronchial and lung epithelium comprises a large surface between host and environment and is attacked as a primary target during lung infection. Besides acting as a mechanical barrier, recent evidence suggests that the lung epithelium functions as an important sentinel system against pathogens. Equipped with transmembranous and cytosolic pathogen-sensing pattern recognition receptors the epithelium detects invading pathogens. A complex signalling results in epithelial cell activation, which essentially participates in initiation and orchestration of the subsequent innate and adaptive immune response. In this review we summarize recent progress in research focussing on molecular mechanisms of pathogen detection, host cell signal transduction, and subsequent activation of lung epithelial cells by pathogens and their virulence factors and point to open questions. The analysis of lung epithelial function in the host response in pneumonia may pave the way to the development of innovative highly needed therapeutics in pneumonia in addition to antibiotics.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / biosynthesis
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Animals
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Cross Infection / immunology*
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Cross Infection / microbiology
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Cytosol / immunology
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Cytosol / microbiology
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Epithelial Cells / immunology
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Epithelial Cells / microbiology
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Epithelium / immunology*
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Epithelium / metabolism
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Epithelium / microbiology*
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Gene Expression Regulation
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Humans
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Immunity, Innate
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Interferon Regulatory Factors / biosynthesis
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Interferon Type I / biosynthesis
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Interferon Type I / genetics
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Intracellular Signaling Peptides and Proteins / immunology
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Intracellular Signaling Peptides and Proteins / metabolism
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Lung / immunology*
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Lung / microbiology*
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Lung / virology
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NF-kappa B / biosynthesis
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Nod1 Signaling Adaptor Protein
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Nod2 Signaling Adaptor Protein
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Pneumonia, Pneumococcal / immunology*
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Pneumonia, Pneumococcal / microbiology
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Pneumonia, Viral / immunology*
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Pneumonia, Viral / microbiology
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Receptors, G-Protein-Coupled / immunology
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Receptors, Pattern Recognition / immunology
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Respiratory Syncytial Virus Infections / immunology*
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Respiratory Syncytial Virus Infections / microbiology
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Signal Transduction*
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Toll-Like Receptors / immunology
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Virulence Factors / immunology
Substances
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Adaptor Proteins, Signal Transducing
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Interferon Regulatory Factors
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Interferon Type I
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Intracellular Signaling Peptides and Proteins
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NF-kappa B
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NOD1 protein, human
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NOD2 protein, human
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Nod1 Signaling Adaptor Protein
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Nod2 Signaling Adaptor Protein
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Receptors, G-Protein-Coupled
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Receptors, Pattern Recognition
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Toll-Like Receptors
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Virulence Factors