Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1

Proc Am Thorac Soc. 2005;2(1):68-70. doi: 10.1513/pats.200404-029MS.

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Hypoxia*
  • Chronic Disease
  • DNA-Binding Proteins / metabolism*
  • DNA-Binding Proteins / physiology
  • Humans
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Lung / metabolism
  • Lung / physiopathology*
  • Mice
  • Mice, Knockout
  • Neovascularization, Pathologic / chemically induced
  • Nuclear Proteins / metabolism*
  • Nuclear Proteins / physiology
  • Oxygen / metabolism*
  • Pulmonary Disease, Chronic Obstructive / metabolism
  • Pulmonary Disease, Chronic Obstructive / physiopathology*
  • Transcription Factors / metabolism*
  • Transcription Factors / physiology

Substances

  • DNA-Binding Proteins
  • HIF1A protein, human
  • Hif1a protein, mouse
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Nuclear Proteins
  • Transcription Factors
  • Oxygen