Abstract
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed.
MeSH terms
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Animals
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Cell Hypoxia*
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Chronic Disease
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DNA-Binding Proteins / metabolism*
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DNA-Binding Proteins / physiology
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Humans
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Lung / metabolism
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Lung / physiopathology*
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Mice
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Mice, Knockout
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Neovascularization, Pathologic / chemically induced
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Nuclear Proteins / metabolism*
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Nuclear Proteins / physiology
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Oxygen / metabolism*
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Pulmonary Disease, Chronic Obstructive / metabolism
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Pulmonary Disease, Chronic Obstructive / physiopathology*
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Transcription Factors / metabolism*
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Transcription Factors / physiology
Substances
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DNA-Binding Proteins
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HIF1A protein, human
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Hif1a protein, mouse
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Nuclear Proteins
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Transcription Factors
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Oxygen