Reduction of carboxyhaemoglobin levels in the venous blood of cigarette smokers following the administration of carbogen

Graham Macdonald; Natalie Kondor; Vandad Yousefi; Alex Green; Frances Wong; Christina Aquino-Parsons

doi:10.1016/j.radonc.2004.09.002

Reduction of carboxyhaemoglobin levels in the venous blood of cigarette smokers following the administration of carbogen

Radiother Oncol. 2004 Dec;73(3):367-71. doi: 10.1016/j.radonc.2004.09.002.

Authors

Graham Macdonald¹, Natalie Kondor, Vandad Yousefi, Alex Green, Frances Wong, Christina Aquino-Parsons

Affiliation

¹ Department of Radiation Oncology, Vancouver Cancer Centre, BC Cancer Agency, Vancouver, BC, Canada.

PMID: 15588884
DOI: 10.1016/j.radonc.2004.09.002

Abstract

Cigarette smokers have high carboxyhaemoglobin levels which can promote tumour radioresistance. Inhalation of carbogen gas shortens the half-life of carboxyhaemoglobin, increasing tumour radiosensitivity in animal models. Breathing 2.5% carbogen for 30 min results in a greater reduction in venous blood COHb levels than breathing 5% carbogen for 7 min.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Carbon Dioxide / administration & dosage*
Carbon Dioxide / pharmacology*
Carboxyhemoglobin / analysis*
Carboxyhemoglobin / metabolism*
Cell Hypoxia
Female
Half-Life
Humans
Male
Middle Aged
Neoplasms / radiotherapy
Oxygen / administration & dosage*
Oxygen / pharmacology*
Radiation Tolerance
Radiation-Sensitizing Agents / administration & dosage*
Radiation-Sensitizing Agents / pharmacology*
Radiotherapy
Smoking / adverse effects*

Substances

Radiation-Sensitizing Agents
Carbon Dioxide
carbogen
Carboxyhemoglobin
Oxygen