Abstract
A 65-yr-old man developed increasing dyspnea and fulminant respiratory failure 48 h after introduction of hydroxyurea, oral cytarabine ocfosfate (YNK01) and interferon-alpha for treatment of Philadelphia chromosome-positive chronic myelogenous leukemia. The chest radiograph showed bilateral patchy infiltrates while computed tomography revealed multiple bullas, ground glass opacities, and patchy consolidations with possible cavitation. Bronchoscopic examination was normal and microbiological tests performed on all biologic fluids were negative. The patient did not respond to multiple antibiotic treatment and corticosteroid administration and died of progressive respiratory failure 5 d after chemotherapy introduction. The postmortem lung examination was consistent with the diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP).
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Arabinonucleotides / administration & dosage
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Arabinonucleotides / adverse effects*
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Cryptogenic Organizing Pneumonia / chemically induced*
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Cryptogenic Organizing Pneumonia / diagnosis
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Cryptogenic Organizing Pneumonia / pathology
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Cytidine Monophosphate / administration & dosage
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Cytidine Monophosphate / adverse effects*
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Cytidine Monophosphate / analogs & derivatives*
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Fatal Outcome
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Humans
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Hydroxyurea / administration & dosage
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Hydroxyurea / adverse effects*
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Interferon-alpha / administration & dosage
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Interferon-alpha / adverse effects*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
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Lung / pathology
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Male
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Radiography, Thoracic
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Tomography, X-Ray Computed
Substances
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Arabinonucleotides
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Interferon-alpha
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1-arabinofuranosylcytosine-5'-stearylphosphate
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Cytidine Monophosphate
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Hydroxyurea