Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients

Meriem Ben-Ali; Mohamed-Ridha Barbouche; Soufia Bousnina; Abdellatif Chabbou; Koussay Dellagi

doi:10.1128/CDLI.11.3.625-626.2004

Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients

Clin Diagn Lab Immunol. 2004 May;11(3):625-6. doi: 10.1128/CDLI.11.3.625-626.2004.

Authors

Meriem Ben-Ali¹, Mohamed-Ridha Barbouche, Soufia Bousnina, Abdellatif Chabbou, Koussay Dellagi

Affiliation

¹ Laboratoire d'Immunologie, de Vaccinologie et de Génétique Moléculaire, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis, Tunisia.

Abstract

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

Publication types

Comparative Study

MeSH terms

Adult
Aged
Base Sequence
DNA / chemistry
DNA / genetics
DNA / isolation & purification
DNA Mutational Analysis
Gene Frequency / genetics
Genetic Predisposition to Disease / genetics*
Genotype
Heterozygote
Humans
Membrane Glycoproteins / genetics*
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Receptors, Cell Surface / genetics*
Toll-Like Receptor 2
Toll-Like Receptors
Tuberculosis, Pulmonary / diagnosis
Tuberculosis, Pulmonary / genetics*
Tunisia

Substances

Membrane Glycoproteins
Receptors, Cell Surface
TLR2 protein, human
Toll-Like Receptor 2
Toll-Like Receptors
DNA