Abstract
Among 2,901 new smear-positive tuberculosis cases in Ho Chi Minh City, Vietnam, 40 cases of treatment failure and 39 relapsing cases were diagnosed. All initial and follow-up Mycobacterium tuberculosis isolates of these case-patients had (nearly) identical restriction fragment length polymorphism patterns, and the Beijing genotype was a significant risk factor for treatment failure and relapse (odds ratio 2.8, 95% confidence interval 1.5 to 5.2).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antitubercular Agents / therapeutic use*
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Case-Control Studies
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Female
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Genotype
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Humans
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Male
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Middle Aged
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / growth & development
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Polymorphism, Restriction Fragment Length
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Recurrence
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Sputum / microbiology
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Treatment Failure
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Tuberculosis / drug therapy*
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Tuberculosis / microbiology*
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Vietnam
Substances
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Antitubercular Agents
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DNA, Bacterial