Abstract
The expression of MHC class I molecules protects cells against lysis by natural killer (NK) cells. It is possible that NK cells are 'educated' to recognize self MHC class I molecules and that the combination of self peptide and MHC class I molecule blocks NK-mediated lysis. Here, Rogier Versteeg compares and contrasts models of education and self-nonself discrimination by T cells and NK cells, and presents a hypothesis for the evolution of T cells from NK cells.
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, Neoplasm / immunology
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Histocompatibility Antigens Class I / immunology*
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Immune Tolerance*
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Killer Cells, Natural / immunology*
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Lymphoma / immunology
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Mice
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Mice, Inbred C57BL / immunology
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Models, Biological*
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Molecular Sequence Data
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Peptide Fragments / immunology
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Selection, Genetic
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Sequence Homology
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T-Lymphocytes / immunology*
Substances
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Antigens, Neoplasm
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Histocompatibility Antigens Class I
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Peptide Fragments