Nontuberculous mycobacterial infections in pediatric acute leukemia

J Pediatr Hematol Oncol. 2002 Oct;24(7):558-60. doi: 10.1097/00043426-200210000-00013.

Abstract

We report on 3 children undergoing treatment for acute lymphoblastic leukemia (ALL), who developed systemic nontuberculous mycobacterial (NTM) infections. All 3 patients were treated successfully with 5 months or less of antimicrobial therapy and completed their chemotherapy with no further recurrence of their NTM infection. NTM infections in some children with ALL may be successfully treated with antimicrobial agents without necessarily compromising the ALL treatment. The optimal duration of therapy for NTM remains unclear, but may be shorter than previously reported.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Clarithromycin / adverse effects
  • Clarithromycin / therapeutic use
  • Female
  • Humans
  • Male
  • Mycobacterium Infections, Nontuberculous / complications*
  • Mycobacterium Infections, Nontuberculous / drug therapy
  • Mycobacterium Infections, Nontuberculous / microbiology*
  • Mycobacterium avium-intracellulare Infection / complications
  • Mycobacterium avium-intracellulare Infection / drug therapy
  • Mycobacterium avium-intracellulare Infection / microbiology
  • Mycobacterium chelonae / isolation & purification
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / microbiology*
  • Rifampin / adverse effects
  • Rifampin / therapeutic use

Substances

  • Clarithromycin
  • Rifampin